Discussion of current scientific literature regarding chiropractic principles and philosophy of the subluxation model. Neuromusculoskeletal and visceral conditions are discussed with the subluxation model of facilitation and adaptation in mind. Particular emphasis is placed on evidence related to the reciprocal influence between dysfunction of the neuromusculoskeletal system and related dysfunction in other systems. The influences of subluxation and the effects of chiropractic care and the adjustment on the health of the entire body are also stressed.